Start Nielsen linus cam4

Nielsen linus cam4

We analysed gene expression signatures specifically associated with the development of bone metastases.

We have identified a novel 15-gene expression signature associated with the development of bone metastases in breast cancer patients.

This bone metastasis signature is the first to be identified using a supervised classification approach in a large series of patients and will help forward research in this area towards clinical applications.].

Along with the hormone status, tumour size and tumour grade, we found that patients who developed visceral metastasis had worse survival outcome, in terms of metastasis-specific survival and overall survival and additionally they frequently developed multiple metastasis during the course of the disease.

We have concluded that tumour types were associated with survival and pattern of distant metastasis during the course of the disease.

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Hereafter they have validated these gene expression signatures in several cohorts of primary breast tumours with known metastatic disease.